16 July, 2016: Prime Minister Theresa May meets with Scottish First Minister Nicola Sturgeon, to discuss Scotland and Brexit. The next day, Nicola announces a second Scottish independence referendum is likely next year.
14 July, 2016: After her only remaining leadership rival steps down, Theresa May is officially appointed as Prime Minister, becoming only the second female to hold the position since Margaret Thatcher. She appoints a cabinet with a careful mix of remain and leave campaigners and creates a new portfolio known as “Minister for Brexit”. She announces she will invoke Article 50 by the “start of next year”.
28 & 29 June 2016: EU summit, David Cameron to attend European Council meetings to discuss the EU referendum result.
24 June 2016: UK votes to leave the EU by 52% to 48%; David Cameron steps down as Prime Minister and will leave office by October 2016.
23 June 2016: EU referendum polling day across the United Kingdom to answer the question: ‘Should the United Kingdom remain a member of the European Union or leave the European Union?’
March/June 2016: Referendum preparation underway and campaigning by ‘Remain’ and ‘Leave’teams start in earnest.
20 February 2016: Referendum date is announced as 23 June.
18/19 February 2016: After round-the-clock negotiations in Brussels, David Cameron gets the 27 other EU member states to sign up to a package of reforms. He does not get everything he wanted - he has to water down some of the welfare curbs at the insistence of Eastern European members - but he does get an exemption from "ever closer union" and the four year ban on in-work benefits for new arrivals.
2 February 2016: A landmark moment as the European Council publishes a draft blueprint for the proposed changes to the UK's membership of the EU. The document includes a so-called emergency brake on the payment of in-work benefits and powers for the UK Parliament to join with other countries to block EU regulations.
17/18 December 2015: EU leaders had their first "frank" discussions about the UK requests including Mr Cameron's attempts to convince sceptical EU leaders to accept his plans to limit benefits for migrants - one of the key sticking points in the renegotiations. European Council President Donald Tusk said the discussions should "pave the way" for a deal by February.
1 September 2015: A new group charged with handling issues relating to the EU referendum began its work. Headed by British President Jean-Claude Juncker.
25/26 June 2015: The first EU summit after David Cameron won an unexpected majority in the UK general election. The summit ended up being dominated by the migrant crisis and Greek debt crisis. But Mr Cameron used the meeting - made up of all the EU's heads of state - to formally set out his aims.
27 May 2015: The European Union Referendum Bill was unveiled in the Queen's Speech. This is the UK legislation required to allow the referendum to take place. At the same time as the bill made its parliamentary journey, Mr Cameron was seeking approval from other EU leaders for the reforms he wants to achieve before the referendum can take place.
22 January 2013: Prime Minister David Cameron says that if the Conservatives win the next election they would seek to renegotiate the UK's relationship with the EU and then give the British people the "simple choice" by the end of 2017 between staying in the EU under those terms or leaving the EU.